Tubulin Alpha 3E (TUBa3E)

TUBa3E belongs to the tubulin family. Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL). The two remaining human group 3 α-tubulin genes, TUBA3D and TUBA3E, are on chromosome 2q21.1. Some parts of human chromosome 2 are syntenic with mouse chromosome 6 (over 100 genes in the MGI Oxford grid); however, TUBA3D and TUBA3E are not in these syntenic regions. Genes on the telomeric side of human TUBA3E, cent (CCDC115, IMP4, PTPN18) tel, have murine orthologs on mouse chromosome 1B.