Fibrinogen Degradation Product (FDP)

Fibrin degradation product (FDPs), also known as fibrin split products, are components of the blood produced by clot degeneration. These are produced by the action of plasmin on deposited fibrin.The levels of these FDPs rises after any thrombotic event.It can be used to test for disseminated intravascular coagulation.Under normal conditions, the fibrinolytic process is localized on the fibrin clots because alpha2-antiplasmin and the plasminogen activator inhibitors prevent fibrinolysis from spreading. During disseminated intravascular coagulation (DIC), fibrinolysis spreads and becomes systemic, in which case the degradation of circulating fibrinogen will occur. Fragments that occur are very heterogeneous: products derived from fibrin, soluble completes, degradation products from fibrinogen, and from nonstabilized fibrin.