Pro-Insulin Like Growth Factor II E-Peptide (IGFIIE)

Preptin is co-secreted with insulin and amylin from pancreatic beta-cells. The hormone increases insulin secretion from glucose-stimulated beta TC6-F7 cells and also in vivo. Cornish et al (2006) have reported that Preptin stimulates the proliferation of primary fetal rat osteoblasts and osteoblast-like cell lines. Preptin also reduces osteoblast apoptosis induced by serum deprivation. In vivo administration of preptin increases bone area and mineralizing surface in adult mice. Preptin is a recently isolated 34-amino acid peptide hormone that is cosecreted with insulin and amylin from the pancreatic beta-cells. Preptin corresponds to Asp(69)-Leu(102) of pro-IGF-II. Increased circulating levels of a pro-IGF-II peptide complexed with IGF-binding protein-2 have been implicated in the high bone mass phenotype observed in patients with chronic hepatitis C infection.