Tissue Polypeptide Specific Antigen (TPS)

TPS is the specific M3 epitope of TPA has been used as a prognostic parameter for some neoplasms since it was isolated in the serum or urine of some cancer patients.TPS is most frequently elevated in malignant tissues. Serum TPS levels not only reflect tumor mass but also tumor activity and are related with proliferation more than necrosis. Furthermore, elevated TPS levels can also be detected in some benign events such as liver failure, renal failure, gestati-on, generalized infection, and diabetes mellitus(DM). TPS levels in cystic fluid, peritoneal fluid, and blood could be used as a marker for the management of ovarian mass.The value of serum TPS as a complement to CA 19-9 in the detection of pancreatic carcinoma was determined prospectively. TPS and CA 19-9 levels obtained at the time of diagnosis in patients suspected of having chronic pancreatitis or pancreatic carcinoma were evaluated in receiver operating characteristic (ROC) curve analysis.