Amyloid Beta Precursor Protein Binding Protein 1 (APPBP1)

NEDD8-activating enzyme E1 regulatory subunit binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer"""s disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene.The APPBP1 protein is 39% identical to the protein encoded by the Arabidopsis auxin resistance gene AXR1; both proteins are relatives of ubiquitin-activating enzyme-1 (UBE1).