Amyloid Beta Precursor Protein Binding Protein 2 (APPBP2)

APPBP2 is a protein interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer"""s disease. This gene has been found to be highly expressed in breast cancer. Multiple polyadenylation sites have been found for this gene.APPBP2 is present as a 70-kD protein in both cytosolic and, together with APP, membrane-associated cell fractions. Immunofluorescence microscopy demonstrated that APPBP2 is present in the Golgi region and that its distribution overlaps that of APP. APPBP2 interacts with microtubules and is functionally associated with APP transport and/or processing.