Calneuron 1 (CALN1)

Calcium-binding protein 8 is a protein with high similarity to the calcium-binding proteins of the calmodulin family. The encoded protein contains two EF-hand domains and potential calcium-binding sites. Alternative splicing results in multiple transcript variants. Calneuron 1 negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. May play a role in the physiology of neurons and is potentially important in memory and learning. Interacts with PI4KB. This binding competes with FREQ/NCS1 binding in a calcium-dependent manner. The mouse orthologous gene (Caln1) shows little prenatal expression, with highest expression at Postnatal Day 21. I CALN1 has a significant role in the physiology of neurons and is potentially important in memory and learning.