Calsyntenin 1 (CLSTN1)

Calsyntenins (Csts, CLSTN) are type type I transmembrane proteins that belong to the cadherin superfamily,Their name comes from their ability to bind Calcium. In birds and mammals, they consist of three family members (Cst1, 2 and 3). Cst1 was first shown to be predominantly expressed in postsynaptic membranes of excitatory neurons, Cst2 and 3 were found in an increased manner in inhibitory GABAergic neurons . The Calsyntenins were shown to interact with numerous proteins such as with kinesin-1 and the APP-linker protein X11L/Mint2) and were shown to have multi-purpose functions within and outside the nervous system. Expressed in the brain and, a lower level, in the heart, skeletal muscle, kidney and placenta. Accumulates in dystrophic neurites around the amyloid core of Alzheimer disease senile plaques.