Cholinergic Receptor, Nicotinic, Alpha 10 (CHRNa10)

Cholinergic receptor, nicotinic, alpha 10, also known as CHRNA10, is a subunit of the nicotinic acetylcholine receptor (nAchR).This nAchR subunit is required for the normal function of the olivocochlear system which is part of the auditory system. Furthermore selective block of α9α10 nicotinic acetylcholine receptors by the conotoxin RgIA has been shown to be analgesic in an animal model of nerve injury pain.Expressed in inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells and peripheral blood lymphocytes.It has features characteristic of the CHRNA family, including 4 hydrophobic regions, which correspond to membrane-spanning regions I through IV, and 4 signature cysteine residues near the putative ligand-binding domain.