Chondroitin Sulfate Proteoglycan 5 (CSPG5)

Chondroitin sulfate proteoglycan 5 is a protein encoded by the CSPG5 gene.Yasuda et al. (1998) cloned CSPG5 from a human brain cDNA library, using a rat cDNA homolog as probe. The deduced 539-amino acid protein has a multidomain structure consisting of an N-terminal signal sequence, a chondroitin sulfate-attachment domain, an acidic amino acid cluster, an EGF-like domain, a transmembrane domain, and a cytoplasmic tail. The human and rat proteins share 86% homology. Northern blot analysis detected restricted expression of a 2.4-kb transcript in brain. A faint 5.2-kb band was detected in heart. Neuroglycan C (NGC) is a transmembrane chondroitin sulfate proteoglycan expressed predominantly in the brain that possesses an EGF-like extracellular domain.