Dihydropyrimidinase Like Protein 2 (DPYSL2)

The DPYSL2 protein has 572 amino acids. Northern blot analysis detected a 4.9-kb DPYSL2 transcript in all tissues examined except liver.Expression of the nonphosphorylated form of CRMP2 or inhibition of GSK3-beta induced the formation of multiple axon-like neurites in hippocampal neurons. Expression of constitutively active GSK3-beta impaired neuronal polarization, whereas the nonphosphorylated form of CRMP2 counteracted the inhibitory effects of GSK3-beta, indicating that GSK3-beta regulates neuronal polarity through phosphorylation of CRMP2. Treatment of hippocampal neurons with neurotrophin-3 (NT3) induced inactivation of GSK3-beta and dephosphorylation of CRMP2.