Dihydropyrimidinase Like Protein 4 (DPYSL4)

Byk et al. (1998) identified human ESTs representing ULIP4 that were isolated from a brain cDNA library. Using one of these sequences as probe, they cloned mouse Ulip4 from a whole newborn mouse brain cDNA library. The deduced 572-amino acid protein contains several phosphorylation consensus sites conserved in other Ulip proteins. Northern blot analysis of several mouse tissues detected Ulip4 expression only in brain. RNA dot blot analysis of developing whole rat brain showed an increase in Ulip4 expression between embryonic and perinatal stages, and slightly lower expression in adult animals.By EST database analysis, they identified a clone encoding a deduced 572-amino acid protein that is 92% identical to mouse Ulip4.