Dihydropyrimidinase Like Protein 5 (DPYSL5)

Members of the CRMP family, such as DPYSL5 contains 2 central WD repeats, as well as several consensus phosphorylation sites. It shares 57% amino acid identity with rat Dpys and about 50% identity with other Crmps. Cram mRNA became detectable in the brains of embryonic rats at embryonic day 14. Expression increased until postnatal day 1, then decreased to very low levels in adult rat brains.The deduced 564-amino acid protein contains several consensus phosphorylation sites. It shares about 51% amino acid identity with mouse Dpys and 49 to 50% identity with other Crmps. Northern blot analysis of several mouse tissues detected a transcript of about 5.0 kb only in brain. During development, Crmp5 was expressed before embryonic day 11.