Dysbindin Domain Containing Protein 1 (DBNDD1)

DBNDD1, Belongs to the dysbindin family. Dysbindin constituent of the dystrophin-associated protein complex (DPC) of skeletal muscle cells. It is also a part of BLOC-1, or biogenesis of lysosome-related organelles complex 1. Dysbindin was discovered by the research group of Derek Blake via yeast two-hybrid screening for binding partners of α-dystrobrevin. In addition, dysbindin is found in neural tissue of the brain, particularly in axon bundles and especially in certain axon terminals, notably mossy fiber synaptic terminals in the cerebellum and hippocampus. Mutation in the DTNBP1 gene was also shown to cause Hermansky-Pudlak syndrome type 7. In drosophila, dysbindin has been shown to be essential for neural plasticity.