Galanin Receptor 3 (GALR3)

The neuropeptide galanin modulates a variety of physiologic processes including cognition/memory, sensory/pain processing, hormone secretion, and feeding behavior. The human galanin receptors are G protein-coupled receptors that functionally couple to their intracellular effector through distinct signaling pathways. GALR3 is found in many tissues and may be expressed as 1.4-, 2.4-, and 5-kb transcripts. Sequence analysis indicated that the predicted 368-amino acid human GALR3 protein shares 89%, 36%, and 58% identity with rat GALR3, human GALR1, and human GALR2, respectively. GALR3 contains features typical of G protein-coupled receptors, including the 7 transmembrane domains and aromatic amino acid triplet signature sequence adjacent to transmembrane domain 3.