Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2C (GRIN2C)

The NMDA receptors are 1 class of ionotropic glutamate receptors. By screening a human hippocampal cDNA library with a rat Nr2a (GRIN2A) cDNA, Lin et al. (1996) isolated cDNAs encoding GRIN2C, called NR2C by them.the 4.4-kb GRIN2C mRNA was widely expressed in the brain, with the highest level of expression in the cerebellum; this transcript was also found in several other tissues. An additional, slightly larger, transcript was detected in the cerebellum. The sequence of the deduced 1,233-amino acid protein is 88% identical to those of rat and mouse Nr2c. Hydropathy analysis of GRIN2C predicted a large N terminus, 4 hydrophobic regions, and a large C terminus.The findings suggested that neuregulins regulate the composition of neurotransmitter receptors in maturing synapses in the brain.