Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 3A (GRIN3A)

Glutamate [NMDA] receptor subunit 3A is a subunit of the N-methyl-D-aspartate (NMDA) receptors, which belong to the superfamily of glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous system. This subunit shows greater than 90% identity to the corresponding subunit in rat. Studies in the knockout mouse deficient in this subunit suggest that this gene may be involved in the development of synaptic elements by modulating NMDA receptor activity.When coexpressed in Xenopus oocytes, NR3A or NR3B coassembles with NR1 to form excitatory glycine receptors that are unaffected by glutamate or NMDA, and inhibited by D-serine, a coactivator of conventional NMDA receptors.