Glycine Receptor Alpha 1 (GLRa1)

Glycine Receptor Alpha 1 is the alpha-1 subunit of the glycine receptor, a ligand-gated chloride channel. This inhibitory glycine receptor mediates postsynaptic inhibition in the spinal cord and other regions of the central nervous system. It is a pentameric receptor composed of alpha and beta subunits. (Grenningloh et al., 1990). The GLRB gene (138492) encodes the beta subunit of the receptor.From a human fetal brain cDNA library, Grenningloh et al. (1990) isolated 2 cDNAs encoding 2 forms of the strychnine-binding subunit of the inhibitory glycine receptor, alpha-1 and alpha-2 (GLRA2; 305990). The predicted 449-amino acid sequence of GLRA1 shows approximately 99% identity to the rat 48-kD polypeptide.