Neurexophilin 4 (NXPH4)

Mammalian neurexophilin was discovered as a 29-kD neuronal glycoprotein that copurifies in a tight complex with neurexin I-alpha . By searching sequence databases using the amino acid sequence of mammalian neurexophilin as the query, Missler and Sudhof (1998) identified human ESTs corresponding to neurexophilins-1 (NXPH1), -2 (NXPH2), -3 (NXPH3), and -4 (NXPH4). Comparison of the amino acid sequences of human, rat, mouse, and bovine neurexophilins revealed that neurexophilins share a common predicted structure composed of 5 domains: an N-terminal signal peptide, a variable N-terminal domain, a highly conserved central domain that is N-glycosylated, a short linker region, and a conserved C-terminal domain that is cysteine-rich.