Nucleoporin Like Protein 1 (NUPL1)

This gene encodes a member of the nucleoporin family that shares 87% sequence identity with rat nucleoporin p58. The protein is localized to the nuclear rim and is a component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. By sequencing clones obtained from a size-fractionated brain cDNA library, Ishikawa et al. (1997) cloned NUPL1, which they designated KIAA0410. The deduced 485-amino acid protein has a calculated molecular mass of about 53 kD. NUPL1 shares 87% sequence identity with rat nucleoporin p58. RT-PCR detected low-level NUPL1 expression in all tissues examined.