Pituitary Adenylate Cyclase Activating Polypeptide Receptor 1 (PACAPR)

Adenylate cyclase activating polypeptide 1 (pituitary) receptor type I is a receptor binds pituitary adenylate cyclase activating peptide.PAC1 is a membrane-associated protein and shares significant homology with members of the G-protein coupled class B glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase.Alternative splicing of two exons of this gene generates four major splice variants, but their full-length nature has not been determined. PAC1 is expressed in the adrenal medulla, pancreatic acini, uterus, myenteric plexus and brain.