Regulating Synaptic Membrane Exocytosis 3 (RIMS3)

By sequencing clones obtained from a human immature myeloid cell line cDNA library, Nagase et al. (1996) cloned RIMS3, which they designated KIAA0237. The deduced 308-amino acid protein has a glycosyl hydrolase motif. Northern blot analysis detected RIMS3 expression in all tissues examined, with highest expression in brain.Wang et al. (2000) cloned rat Rims3, which they called Nim3, and identified human RIMS3 by database analysis. The deduced protein contains a C2B domain and is highly homologous to the C-terminal parts of RIMS1 and RIMS2, but it lacks all of the N-terminal domains of RIMS1 and RIMS2. Northern blot analysis of rat tissues detected Rims3 expression in brain only.