Repulsive Guidance Molecule B (RGMB)

RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the repulsive guidance molecule family and contributes to the patterning of the developing nervous system.The deduced 436-amino acid mouse Rgmb protein is predicted to be a GPI-anchor protein with an N-terminal signal peptide and C-terminal hydrophobic domain. Rgmb shares 50 to 60% homology with Rgma and hemojuvelin.  Rgmb expression was detected primarily in fetal mouse DRG, dorsomedial mantle layer of the spinal cord, alar plate of the myelencephalon, marginal layer of the mesencephalon, basal plate of the pons, and cerebellar primordia, as well as the cortex of the olfactory lobe, retina, and olfactory epithelium.