Reticulon 3 (RTN3) - Ретикулон-3

The mRNA for RTN3 was approximately 3-fold more abundant in macula than in peripheral retina. The 2,527-bp cDNA encodes a predicted 236-amino acid protein that shows strong sequence similarity with other members of the RTN gene family. RTN3 is widely expressed in human tissues, with highest expression in the brain.BACE1 colocalized with RTN3 in neurons of human brain gray matter, and with RTN4 in oligodendrocytes in white matter.Overexpression of RTN3 in vitro inhibited BACE1 activity and decreased amyloid precursor protein (APP) processing. The findings suggested that reticulon proteins are negative modulators of BACE1 activity, and that RTN3 specifically blocks access of BACE1 to APP within neurons.