Retinoblastoma Binding Protein 7 (RBBP7)

RBBP7 is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation.The predicted 425-amino acid human RBBP7 protein is identical to mouse Rbbp7, except for 1 conserved amino acid substitution, and is 89% identical to human RBBP4. RBBP7 contains internal trp-asp (WD) repeats which are conserved with those of RBBP4.