Retinoblastoma Like Protein 2 (RBL2)

Mayol et al. (1993) cloned a retinoblastoma-related human gene, referred to as RB2, on the basis of sequence homology of the E1A-binding domain of the retinoblastoma gene (RB1). Structural homology with RB1 suggested a possible function of RB2 as a tumor suppressor gene. RBL2 has a molecular mass of about 120 kD.Kong et al. (2006) found that RBL2 and RINT1 were essential for telomere length control in human fibroblasts, with loss of either protein leading to longer telomeres. They proposed that RBL2 forms a complex with RAD50 (604040) through RINT1 to block telomerase-independent telomere lengthening. Baldi et al. (1996) characterized the organization and 5-prime flanking region of the Rb2, or p130, gene. They determined that the gene contains 22 exons and spans over 50 kb.