Rhombotin Like Protein 2 (RHOM3)

Rabbitts et al. (1991) found that the RHOM3 gene was transcribed mainly in the brain.Using subtractive hybridization to identify genes upregulated by dopamine in rat cerebral astrocytes, followed by screening a human fetal brain cDNA library, Shi et al. (2001) cloned LMO3.Rabbitts et al. (1991) found that the RHOM3 gene is located on chromosome 12p13.Boehm et al. (1991) identified a third rhombotin-like gene (RBTN3) and determined that it is not situated on chromosome 11. It shows, however, 93% homology with rhombotin-2 and also encodes a LIM domain protein. It is not known whether the RHOM3 gene is associated with chromosomal abnormalities in leukemia. The rhombotin gene on 11p15 is a consistent but rare feature of a subset of T-ALL.