Ryanodine Receptor 3 (RYR3)

Ryanodine receptor 3 is a protein encoded by this gene is both a calcium channel and a receptor for the plant alkaloid ryanodine. RYR3 along with RYR1 control the resting calcium ion concentration in skeletal muscle. The deduced 4,866-amino acid protein has a calculated molecular mass of about 551 kD. RYR3 contains 4 repeated sequences organized into 2 tandem pairs, as well as 4 highly hydrophobic C-terminal segments. It does not have an N-terminal signal sequence. Northern blot analysis detected a 16-kb transcript expressed at high levels in caudate nucleus, amygdala, and hippocampus, and at lower levels in corpus callosum, substantia nigra, and thalamus. Abundant expression was also detected in skeletal muscle, and a faint signal was detected in heart.