Synaptotagmin XI (SYT11)

SYT11 is a member of the synaptotagmin gene family and encodes a protein similar to other family members that are known calcium sensors and mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. The encoded protein is also a substrate for ubiquitin-E3-ligase parkin. The gene has previously been referred to as synaptotagmin XII but has been renamed synaptotagmin XI to be consistent with mouse and rat official nomenclature.The transcript contains 2 Alu repeats in the 3-prime UTR. SYT11 shares 57.3% identity with mouse Syt4 over 103 amino acids. Northern blot analysis detected SYT11 expression in all tissues examined, with highest expression in brain and lung and lowest expression in skeletal muscle. No expression was detected in HeLa cells.