Synuclein Alpha Interacting Protein 1 (SNCaIP1)

Synphilin-1 is a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif.The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a role in the formation of cytoplasmic inclusions and neurodegeneration. Widely expressed, with highest levels in brain, heart and placenta.A mutation in this gene has been associated with Parkinson"""s disease. Alternatively spliced transcript variants encoding different isoforms of this gene have been described, but their full-length nature has yet to be determined.