Tubulin Alpha 1B (TUBa1B)

TUBA1B expression was upregulated in HCC tumor tissues and proliferating HCC cells, and an increased TUBA1B expression was associated with poor overall survival and resistance to paclitaxel of HCC patients.The human counterpart of the mouse tubulin gene M-alpha-2 is the k-alpha-1 gene, cloned from a human keratinocyte cDNA library by Cowan et al. (1983). The k-alpha-1 gene encodes a predicted 451-amino acid protein that differs from the b-alpha-1 protein by only one amino acid. By Northern blotting, k-alpha-1 mRNA was expressed in all tissues tested. By Northern blot analysis and in situ hybridization, Miller et al. (1987) found that the rat homolog of k-alpha-1, which they called T26, is expressed constitutively at a low level in most or all neural cell types throughout development, with some enrichment in proliferative zones.