Vesicle Associated Membrane Protein 8 (VAMP8)

VAMP8 is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. It is associated with the perinuclear vesicular structures of the early endocytic compartment.It has been found that VAMP8 interacts specifically with the soluble NSF-attachment protein (alpha-SNAP), most likely through an VAMP8-containing SNARE complex.The deduced 101-amino acid protein contains an amphipathic helix that may participate in coiled-coil interactions and a C-terminal hydrophobic domain predicted to serve as a membrane anchor. Transfection of Vamp8 into normal rat kidney cells resulted in broadly distributed puncta throughout the cell with a juxtanuclear enrichment.