Anoctamin 1 (ANO1)

TMEM16A, which encodes a deduced 986-amino acid protein. A shorter TMEM16A isoform results from alternative splicing. The human and mouse TMEM16A proteins share 89.9% sequence identity; both have 8 potential transmembrane regions with the N- and C-terminal tails facing the cytoplasm, 5 potential N-linked glycosylation sites, and a tyrosine phosphorylation site. TMEM16A shares 58.4%, 38.3%, and 38.6% amino acid sequence identity with C12ORF3 (TMEM16B), C11ORF25 (TMEM16C), and FLJ34272 (TMEM16D), respectively.In silico analysis indicated that TMEM16A mRNA is expressed in head and neck tumors, parathyroid tumors, and ovarian tumors, and in breast, pancreatic, gastric, and uterine cancers.