Anoctamin 8 (ANO8)

By searching databases for sequences similar to TMEM16E, Katoh and Katoh (2005) identified the TMEM16H gene.The deduced full-length protein contains 1,232 amino acids. They identified a splice variant that contains an 823-bp insertion corresponding to a retained intron 17 and that results in a C-terminally truncated protein of 1,114 amino acids due to an in-frame stop codon in intron 17. Both full-length TMEM16H and its splice variant contain the 8 transmembrane domains and N and C termini facing the cytoplasm that are characteristic of all TMEM16 family members.Katoh and Katoh (2005) detected TMEM16H expression in embryonic stem cells, fetal brain, and neural tissues.expression in all adult tissues and all specific brain regions examined, with highest expression in the cerebellum and substantia nigra.