Breast Carcinoma Amplified Sequence 3 (BCAS3)

The BCAS3 gene is regulated by estrogen receptor alpha (ER-α). The PELP1 protein acts as a transcriptional coactivator of estrogen receptor induced BCAS3 gene expression. In addition BCAS3 possesses histone acetyltransferase activity and itself appears to act as a coactivator of ER-α. Furthermore BCAS3 requires PELP1 to function as a coactivator in ER-α. The deduced 913-amino acid protein has a calculated molecular mass of 99 kD. Northern blot analysis revealed a 3.9-kb transcript expressed in all tissues examined. Several smaller transcripts showed tissue-specific distribution. Multiple tissue expression array analysis indicated ubiquitous expression, with highest levels in stomach, liver, lung, kidney, fetal kidney, prostate, testis, thyroid gland, and adrenal gland.