C-Myc Promoter Binding Protein (MYCPBP)

Stasiv et al. (1994) reported the cloning of a cDNA encoding a c-myc promoter-binding protein called IRLB. The predicted amino acid sequence contains a putative alpha-helical DNA binding region. Bacterially expressed protein was shown to bind to the ISRE (interferon-stimulated response element) of the c-myc promoter.Myc (c-Myc) codes for a protein that binds to the DNA of other genes and is therefore a transcription factor. When a gene like Myc is altered to cause cancer, the cancerous version of the gene is called an oncogene. The healthy version of the gene that it is derived from is called a proto-oncogene.A mutated version of Myc is found in many cancers which causes Myc to be persistently expressed.Myc protein belongs to Myc family of transcription factors, which also includes N-Myc and L-Myc genes.