C-Ros Oncogene 1, Receptor Tyrosine Kinase (ROS1)

This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. C-Ros Oncogene 1 is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor.ROS1 encodes a protein tyrosine kinase with a potential transmembrane domain. It arose from the human ROS1 gene by a rearrangement introduced during gene transfer, which deleted the putative extracellular domain of ROS1, leaving potential transmembrane and intracellular protein tyrosine kinase domains intact.It contains an intracellular domain typical of tyrosine protein kinases, a transmembrane domain, a very large extracellular domain that contains 31 potential N-linked glycosylation sites, and a putative N-terminal signal peptide.