Cancer/Testis Antigen 1B (CTAG1B)

Cancer/testis antigens, such as CTAG1B, are expressed in a variety of malignant tumors but soley in testis among normal adult tissues.NYESO1 expression in primary MTC tissues significantly correlated with tumor recurrence. The presence of specific anti-NYESO1 antibodies was searched in the sera of MTC-affected patients examined by ELISA using recombinant NYESO1 protein. A humoral response against this CTA was detected in 6 of 11 NYESO1-expressing patients (54.5%), and in 1 of 6 patients with an NYESO1-negative tumor. Anti-NYESO1 antibodies were present in 15 of 42 sera (35.7%), demonstrating that MTC is a neoplasm frequently associated with humoral immune response to NYESO1.