Cancerous Inhibitor Of PP2A (CIP2A)

CIP2A has a calculated molecular mass of 102.2 kD and has a 255-amino acid coiled-coil region at its C terminus. Immunohistochemical analysis of human and mouse cells detected diffuse cytoplasmic p90 staining, with a slight concentration in the perinuclear region. Expression was high in embryonic day-17.5 and -18.5 mouse liver, and was moderate in embryonic brain, muscle, and epidermal layers. However, p90 was not expressed in adult mouse liver. KIAA1524 gene contains at least 26 exons and spans 92 kb. The 5-prime UTR is GC rich, and the 3-prime UTR contains 2 polyadenylation signals.anti-p90 autoantibodies in HCC, gastric cancer, and esophageal cancer patients. Expression of p90 was elevated in 6 of 11 gastric cancer tissues examined.