Chronic Lymphocytic Leukemia Up Regulated 1 Opposite Strand Protein (CLLU1OS)

CLLU1 expression analysis adds prognostic information to risk prediction in chronic lymphocytic leukemia. High levels of CLLU1 expression were associated with shorter overall survival, with a 7% increase in risk of early death by each doubling of the CLLU1 expression level. Stratification for age at diagnosis demonstrated a strong prognostic significance of CLLU1 expression in patients younger than 70 years, but not in patients aged 70 or older. CLLU1 expression analysis added further prognostic information within all prognostic subgroups, with the exception of patients with unmutated IgV(H) CLL. Only CLLU1 expression and IgV(H) mutational status had independent predictive power. Thus, analysis of CLLU1 expression is highly applicable in risk prediction in CLL for patients of an age eligible for risk stratification.