Coiled Coil Domain Containing Protein 186 (CCDC186)

C10orf118 encoded by this open reading frame is the CTCL tumour antigen L14-2, a factor involved in processes of tumorigenesis. The surrounding regions of HH10 Helix I revealed a clear conservation of eight extra base pairs when compared with the HH9 region. Furthermore, the 50-ends of two expressed sequence tags were observed to match with this intronic region. Regarding the absence of the HH10 motif among some mammal species, a case of an inactive HHR motif was observed in the C10orf118 orthologue of the lagomorph Ochotona princeps, which suggests the loss of this HHR motif during the evolution of these mammals. Interestingly, a putative gene homologous to C10orf118 was detected in the S. mansoni genome. Inspection of the corresponding genomic sequence in the trematode revealed the presence of at least two HHR motifs.