Cutaneous T-Cell Lymphoma Associated Antigen 4 (CTAGE4)

By screening a testis cDNA library using CTAGE1 as probe, Usener et al. (2003) cloned CTAGE4. The transcript is about 2.0 kb long. RT-PCR detected CTAGE4 expression in testis, placenta, and skin, but not in other tissues examined.By genomic sequence analysis, Usener et al. (2003) mapped the CTAGE4 gene to chromosome 7.Using SEREX (serologic analysis of recombinant tumor cDNA expression libraries) to screen for cutaneous T-cell lymphoma (CTCL) antigens in a testis cDNA library, Eichmuller et al. (2001) cloned CTAGE1. Northern blot analysis detected transcripts of about 4.0 and 1.3 kb in testis and in several CTCL cell lines. One cell line expressed additional transcripts of 2.3 and 0.5 kb. RT-PCR of 28 normal tissues detected CTAGE1 expression only in testis.