Cyclin Dependent Kinase Inhibitor 3 (CDKN3)

CDKN3 is an enzyme belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers.CDI1 is expressed at the G1 to S transition, and the protein forms stable complexes with CDK2. In vitro, CDI1 removes phosphate from tyrosine residues in model substrates, but a mutant protein that bears a lesion in the putative active site cysteine does not. Overexpression of wildtype CDI1 delays progression through the cell cycle in yeast and HeLa cells; delay is dependent on CDI1 phosphatase activity. The gene is also symbolized CDKN3 for cyclin-dependent kinase inhibitor 3.