Ets Variant 7 (ETV7)

The ETS (E26 transformation-specific) family of transcription factors, of which ETV7 is a member, is a large group of evolutionarily conserved transcriptional regulators that play an important role in a variety of cellular processes throughout development and differentiation, and are involved in oncogenesis as well.The cDNA, which the authors designated TEL2, encodes a deduced 341-amino acid protein that shares 38% sequence identity with TEL1 (ETV6). TEL2 contains a C-terminal ETS domain and an N-terminal PNT domain, which is thought to mediate protein-protein interactions. Northern blot analysis revealed expression of TEL2 mRNA predominantly in hematopoietic tissues; a predominant band of approximately 1.2 kb was present in fetal liver and bone marrow and was faintly present in peripheral blood leukocytes.