FK506 Binding Protein 14 (FKBP14)

FKBP14, encodes a peptidyl-prolyl isomerase that may be involved in protein folding in the ER. FKBP14 binds with Psn and mediates Psn stability and Notch signalling in vivo. FKBP14 localized to embryonic hemocytes and larval tissues, in addition to being expressed in developing egg chambers. FKBP14 function is required during development, since FKBP14 null mutants are recessive lethal. These mutants exhibited defects in larval disc development that resulted in eye, wing and notum phenotypes reminiscent of Psn dominant-negative and Notch-dependent phenotypes. Furthermore, FKBP14 mutants displayed enhanced apoptosis in larval tissues, suggesting a possible involvement in apoptosis regulation. FKBP14 mutants enhanced Notch loss-of-function phenotypes in the wing.