Family With Sequence Similarity 57, Member A (FAM57A)

The CT120A isoform has an N-terminal signal peptide, 7 transmembrane regions, 6 phosphorylation sites, an N-myristoylation site, and an RGD cell attachment motif. The CT120B isoform lacks a transmembrane region and RGD cell attachment motif due to alternative splicing of exon 4. Northern blot analysis of human tissues detected strong expression in pancreas, moderate expression in heart, placenta, and kidney, low expression in brain, liver, and skeletal muscle, and no expression in lung. CT120 expression was detected in all tumor cell lines examined, with highest levels in a lung adenocarcinoma cell line. Immunocytochemical studies localized CT120 to the plasma membrane in human hepatoma cells.Cells overexpressing CT120B decreased tumor weight when injected into nude mice.