Feline Sarcoma Oncogene (FES)

FES encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.The FES protooncogene encodes a cytoplasmic protein tyrosine kinase implicated in growth factor and cytokine receptor signaling. It is involved myelopoiesis and plays a role in regulating the innate immune response.