Follicular Lymphoma Variant Translocation 1 (FVT1)

Follicular lymphoma variant translocation 1 is a secreted protein which is weakly expressed in hematopoietic tissue. FVT1 shows a high rate of transcription in some T-cell malignancies and in phytohemagglutinin-stimulated lymphocytes. The proximity of FVT1 to BCL2 suggests that it may participate in the tumoral process.Sphingolipids are essential lipid components of the plasma membrane. Together with cholesterol, sphingolipids form lipid microdomains or rafts that are involved in membrane traffic and cell signaling. Synthesis of sphingolipids initiates with condensation of L-serine with palmitoyl-CoA, producing 3-ketodihydrosphingosine (KDS), followed by reduction to dihydrosphingosine by KDS reductases, like FVT1 (Kihara and Igarashi, 2004).