Kelch Domain Containing Protein 10 (KLHDC10)

KLHDC10, Contains 6 Kelch repeats. Expressed in fetal brain, liver, lung, kidney and placenta. Kelch proteins (and Kelch-like proteins) are a widespread group of proteins that contain multiple Kelch motifs. The kelch domain generally occurs as a set of five to seven kelch repeats that form a β-propeller tertiary structure. Kelch-repeat β-propellers are generally involved in protein-protein interactions, though the large diversity of domain architectures and limited sequence identity between kelch motifs make characterisation of the kelch superfamily difficult. Each kelch repeat forms a "blade" of the β-propeller fold, consisting of a four-stranded antiparallel β-sheet secondary structure, arranged radially around a central axis, packed onto its adjoining repeats via hydrophobic contacts.