Kelch Like Protein 10 (KLHL10)

KLHL10 displayed high evolutionary conservation in mammals, as evidenced by 98.7% amino acid identity between mouse and human KLHL10. KLHL10 is expressed exclusively in the cytoplasm of elongating and elongated spermatids.Yan et al. (2004) generated a Klhl10 null allele in mouse embryonic stem cells, and obtained 47 chimeras from 6 independent embryonic stem cell lines.The data demonstrated that, like protamine-1 (PRM1) and protamine-2 (PRM2), both alleles of Klhl10 are required for male fertility and that haploinsufficiency caused by a mutation in 1 allele of Klhl10 prevents genetic transmission of both mutant and wildtype alleles.